Investigation of a Perilla frutescens special extract - Anti-inflammatory and immune-modulatory properties

Perilla frutescens (L.) Britton leaves are used as food and in traditional medicine. A Perilla leaf special extract was used to investigate the anti-inflammatory effects and mode of immune-modulatory properties in the following ex vivo experiments addressing different immune cells. After stimulation, pattern of cytokines were determined and thus information about mode of action derived. As a result, anti-inflammatory effects were seen on the monocytic level with significant reduction of TNF-s production whereas on the T-helper cellular level, reactions were less pronounced but a shift towards a TH2-helper response was identified. Both effects were dose dependent. Results underline the anti-inflammatory and other immune-modulatory properties which might impact the beneficial effects in different indications, like for example irritable bowel syndrome.

Buchwald-Werner S, Fujii H, Schön C, Doebis C

Agro FOOD Industry Hi Tech 2012, 23, 38-41