New Self-Assembling Formulation Technology Improves Transepithelial Transport of Curcuminoids in Vitro and is Capable to Support the Rising Wishes for Sustainable Vegan Nutrition

The relative bioavailability of lipophilic nutritional supplements is largely dependent on the delivery system. This is especially true for curcumin, which is extracted from the turmeric root (Curcuma longa L.) and which is becoming increasingly popular due to its antioxidant, anti-inflammatory and other described health protecting properties. In the present study, we present a new technology as delivery system for lipophilic compounds, the Vitaresorp® technology. In this study, we present comparative data for the transepithelial transport of curcuminoids using the new technology with different phospholipids or powder across the epithelium of the widely used CaCo-2 cell model after an in vitro simulation of the digestion process. The results demonstrate the formation of nanosized particles with improved adherence to intestinal cells and up to 6-fold improved transepithelial transport of curcuminoids compared to powder when delivered with the Vitaresorp® technology.

Engelhart Jentzsch K, Krueckeberg S, Singer TF

Arch Biomed Eng & Biotechnol. 6(1): 2021. ABEB.MS.ID.000632. DOI: 10.33552/ABEB.2021.06.000632