Pilot study on the effect of parenteral vitamin E on ischemia and reperfusion induced liver injury: a double blind, randomized, placebo-controlled trial

Liver surgery usually involves ischemia and reperfusion (I/R) which results in oxidative stress and cell damage. The administration of antioxidants should diminish or prevent this damage. The purpose of this study was to investigate the effect of the antioxidant vitamin E on I/R injury. We carried out a placebo-controlled double-blind study on 68 patients undergoing elective, tumour-related, partial liver resection. 47 patients were qualified for the per protocol population based evaluation. The patients were randomly assigned to two groups.

Bartels M, Biesalski HK, Engelhart K, Sendlhofer G, Rehak P, Nagel E

Clin Nutr. 2004 Dec;23(6):1360-70.