Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

Maintaining healthy blood pressure is fundamental in order to avoid disorders to the heart and blood vessels. In prevention, and alongside pharmacological therapy, the use of natural substances is extremely helpful for pre- and mild hypertensive subjects. Our study was therefore focused on the effects, both in vitro and in humans, of a grape seed extract, Enovita (GSEe), a highly standardized extract in polyphenols of Vitis vinifera L. The in vitro cells model was chosen to explore the extract properties related to vascular inflammation/vasodilation. A randomized, double-blind, placebo-controlled clinical study in healthy volunteers was further performed to investigate GSEe benefits. GSEe resulted in a benefit of modulating endothelial functionality and blood pressure with an overall positive modulation on mood related to stress perception.

Schön C, Allegrini P, Engelhart-Jentzsch K, Riva A, Petrangolini G

Nutrients 2021, 13(2), 654