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09. November 18

Bioavailability Study of Maqui Berry Extract in Healthy Subjects

Several health promoting effects have been reported for maqui berry, rich in anthocyanins. Direct effects of anthocyanins as well as bioactive metabolites might be involved. Within the study, bioavailability of a proprietary standardized maqui berry extract Delphinol® was investigated based on two selected anthocyanins (delphinidin-3-O-glucoside (DS) + cyanidin-3-O-sambubioside (CS)) and two breakdown products (protocatechuic acid (PCA) + gallic acid (GA)) after a single-dose supplementation in humans.


Schön C, Wacker R, Micka A, Steudle J, Lang S, Bonnländer B

Nutrients. 2018 Nov; 10(11): 1720. Published online 2018 Nov 9. doi: 10.3390/nu10111720

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10. September 18

Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects

Each year, adults suffer about two to four upper respiratory tract infections (URTIs), mostly in winter. The aim of the study was to evaluate the effects of brewers' yeast (1,3)-(1,6)-beta-glucan on incidence and severity of upper respiratory tract infections (URTIs).


Dharsono T, Rudnicka K, Wilhelm M, Schoen C

J Am Coll Nutr. 2018 Sep 10:1-11. doi: 10.1080/07315724.2018.1478339

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07. August 18

Blood glucose response after oral intake of lactulose in healthy volunteers: A randomized, controlled, cross-over study

Lactulose can be used as a functional food ingredient. During manufacturing as liquid or crystalline formulation, impurities with different sugars occur. Lactulose may also be consumed by people with impaired glucose tolerance, including diabetics. For these consumers, it is of interest whether the described carbohydrate impurities may increase blood glucose levels after ingestion. This study was performed to investigate possible changes of blood glucose levels after oral intake of 10 g and 20 g of liquid and crystalline lactulose in healthy subjects. The small amounts of carbohydrate impurities did not influence blood glucose levels, indicating potential applicability to people with impaired glucose tolerance.


Steudle J, Schön C, Wargenau M, Pauly L, Schwejda-Güttes S, Gaigg B, Kuchinka-Koch A, Stover JF

World J Gastrointest Pharmacol Ther. Aug 7, 2018; 9(3): 22-30 Published online Aug 7, 2018. doi: 10.4292/wjgpt.v9.i3.22

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09. June 18

Absorption of Hydroxytyrosol from Different Sources and its Impact on Lipid Status in Human Subjects

There is growing interest in the health effects of dietary polyphenols on cardiovascular risk factors. In this context, the effect of hydroxytyrosol on lipid status was investigated in healthy subjects. Hydroxytyrosol, a polyphenol especially known from olive oil, is available on the market from different sources. Absorption from those sources is prerequisite for its effects.


Siefer S, Wacker R, Wilhelm M, Schoen C

J Nutri Med Diet Care 4:025. doi.org/10.23937/2572-3278.1510025

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01. June 18

Hormonal Contraceptive Use Is Associated With Higher Total but Unaltered Free 25-Hydroxyvitamin D Serum Concentrations

Intake of hormonal contraceptives (HC) is associated with higher total 25-hydroxyvitamin D [25(OH)D] concentrations, but the effect of HC on free 25(OH)D is unclear. We investigated whether free 25(OH)D concentrations differ according to use of HC.


Pilz S, Obeid R, Schwetz V, Trummer C, Pandis M, Lerchbaum E, Pieber TR, Obermayer-Pietsch B, Wilhelm M, Hahn A, Schön C

J Clin Endocrinol Metab. 2018 Jun 1;103(6):2385-2391. doi: 10.1210/jc.2018-00336.

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15. May 18

Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study

Due to the successful implementation of vaccination strategies early-life morbidity and mortality due to infectious disease has been reduced dramatically. Vaccines against tetanus and diphtheria are among the most frequently used vaccines worldwide, but various studies in different European countries have shown that protection against tetanus and particularly against diphtheria is unsatisfactory in adults and older persons. In this study we analyzed tetanus- and diphtheria-specific antibody concentrations in 2100 adults of different age from 6 selected European countries (Austria, Belgium, Germany, Greece, Italy, Poland) in order to investigate differences in the level of protection against tetanus and diphtheria across Europe.


Weinberger B, Keller M, Putzer C, Breitenberger D, Koller B, Fiegl S, Moreno-Villanueva M, Bernhardt J, Franceschi C, Voutetakis K, Gonos ES, Hurme M, Sikora E, Toussaint O, Debacq-Chainiaux F, Grune T, Breusing N, Bürkle A, Grubeck-Loebenstein B

Exp Gerontol. 2018 May; 105:109-112. doi: 10.1016/j.exger.2017.08.037. Epub 2017 Oct 7

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