Genotoxicity

Safety tests for chemicals as part of REACH, botanicals (THMP) and cosmetics

The determination of potential genotoxic effects is an essential component of the safety assessment. Applying in vitro testing, a combination of tests is usually used to answer this complex question. Available here are a number of recognised protocols, as well as other standard methods for the measurement of DNA damage.

BioTeSys offers a specific test package for detecting the endpoints chromosome damage and DNA strand breaks. The test methods complement each other and can detect DNA double-strand breaks directly and indirectly.

To determine the cellular toxicity, we offer the in vitro methods:

• Micronucleus assay according to OECD TG 487
• Automated FADU assay
• γ-H2A.X assay

For further information please see our fact sheets on

Genotoxicity testing (Download 986 KB)
Automated GENOTOX-Assay with 3D-skin models (Download 652 KB)