BioTeSys ist active as speaker at public events and publishes scientific articles. You can find an overview of these publications here.
Publication: 17. March 2021
Self-rated health (SRH) is one of the most frequently used indicators in health and social research. We used data from three independent European population samples (N approx. 15,000) to investigate the associations of SRH with 150 biomolecules in blood or urine (biomarkers). Altogether 57 biomarkers representing different organ systems were associated with SRH. We propose three potential pathways through which biomarkers may be incorporated into an individual’s subjective health assessment. Finally our findings indicate that SRH has a solid biological basis and it is a valid but non-specific indicator of the biological condition of the human organism.
Publication: 17. February 2021
Maintaining healthy blood pressure is fundamental in order to avoid disorders to the heart and blood vessels. In prevention, and alongside pharmacological therapy, the use of natural substances is extremely helpful for pre- and mild hypertensive subjects. Our study was therefore focused on the effects, both in vitro and in humans, of a grape seed extract, Enovita (GSEe), a highly standardized extract in polyphenols of Vitis vinifera L. The in vitro cells model was chosen to explore the extract properties related to vascular inflammation/vasodilation. A randomized, double-blind, placebo-controlled clinical study in healthy volunteers was further performed to investigate GSEe benefits. GSEe resulted in a benefit of modulating endothelial functionality and blood pressure with an overall positive modulation on mood related to stress perception.
Publication: 05. January 2021
Skin health, skin appearance and skin beauty are influenced by collagen composition of the dermis. Natural aging affects the structural integrity of the collagen network. Not only collagen peptides, but also micronutrients can beneficially affect skin appearance. Aim of this study was to investigate the effect of a food supplement with collagen hydrolysate and micronutrients on skin beauty. The test product was assessed for its capability to reduce wrinkles and to improve skin hydration and collagen structure.
Publication: 25. November 2020
In a randomized, double blind cross over study, we compared the area under the curve (AUC), Cmax, and Tmax of plasma (6S)-5-Methyl-THF after intakes of (6S)-5-Methyl-THF-Na salt (Arcofolin®) and folic acid. In conclusion, a single oral dose of (6S)-5-Methyl-THF-Na caused higher AUC 0–8 h and Cmax of plasma (6S)-5-Methyl-THF compared to folic acid. The Na- and Ca- salts of (6S)-5-Methyl-THF are not likely to differ in their pharmacokinetics.
Publication: 10. August 2020
Nutraceuticals containing hydroxytyrosol have been shown to exert a wide range of beneficial effects on the cardiovascular system like lipid modification and cholesterol reduction. The aim of this randomized doubleblind, placebo-controlled parallel study was to investigate the effects of a pure, synthetic form of hydroxytyrosol (HTEssence®) on the lipid profile in subjects with elevated LDL-cholesterol level.
Publication: 22. October 2019
Choline is required for numerous biological processes, including the synthesis of neurotransmitters, and it is an important prerequisite for structural integrity and the functioning of cells. This study in healthy volunteers aimed to compare the pharmacokinetics of free choline and of selected choline metabolites between the single dose intake of phosphatidylcholine, present in SuperbaBoostTM krill oil, and choline bitartrate salt.
Publication: 03. September 2019
Dietary bioactive peptides have been, among many functionalities, associated with immune modulation and thereby may improve resolution of inflammation. The goals of this research were to assess (1) whether specific peptides with immune-modulating activity consumed as part of a rice protein hydrolysate could be absorbed into blood and (2) whether they modulate inflammation markers. Artificial intelligence algorithms were applied to target, predict and unlock inflammation-modulating peptides from rice protein.
Publication: 16. August 2019
To overcome the limited oral bioavailability and the absorption variability in humans of CBD, a novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb® formulation technology incorporating CBD, as Hemp-Extract, was developed (SEDDS-CBD). The study objective was to evaluate the pharmacokinetic profile of SEDDS-CBD in a randomized, double-blind, cross-over design in 16 healthy volunteers under fasted conditions.
Publication: 23. July 2019
Milk proteins have been hypothesized to protect against type 2 diabetes (T2DM) by beneficially modulating glycemic response, predominantly in the postprandial status. In the present study, the impact of a milk protein hydrolysate of native whey origin with alpha-glucosidase inhibiting properties was determined in prediabetics in a randomized, cross-over trial.
Publication: 01. July 2019
The use of curcumin as dietary supplement to ameliorate inflammation, arthritis, stomach, skin, liver, and gallbladder problems, is hampered by the lack of oral absorption. In this study, an in vitro digestion method and Caco-2 cell-lines were used to assess the influence of the solubilisation of curcuminoids in a liquid formulation comprising a high content of phosphatidylcholine on the transport of the curcuminoids across a Caco-2 cell monolayer, compared to powdered curcuminoids.