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BioTeSys
publications.
BioTeSys ist active as speaker at public events and publishes scientific articles. You can find an overview of these publications here.
Publication: 30. September 2016 Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries.
Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels
Publication: 29. August 2016 Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study.
Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and directional deregulating events concerning DNA methylation controllers, which may underpin the age-related epigenetic changes. In this context, 5mC-hydroxylases (TET enzymes) are new potential players.
Publication: 05. August 2016 Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation
Constipation is among the most common health impairments in Western countries. This study aimed to determine the effect of the chicory-derived fermentable dietary fiber Orafti® Inulin on stool frequency in healthy subjects with constipation. The study was conducted according to recent guidance documents for investigating bowel function and used a randomized, double-blind, placebo-controlled, cross-over design with a 2-week wash-out phase. Each study period comprised a run-in phase followed by 4 weeks daily intake of 3 × 4g inulin or maltodextrin (placebo). Forty-four healthy volunteers with constipation documented stool frequency and consistency, gastrointestinal characteristics and quality of life. Consumption of Orafti® Inulin significantly increased stool frequency compared to placebo (median 4.0 [IQR 2.5-4.5] versus 3.0 [IQR 2.5-4.0] stools/week, p = 0.038). This was accompanied by a softening of stools and trend toward higher satisfaction versus placebo (p = 0.059). In conclusion, Orafti® Inulin was effective in volunteers with chronic constipation and significantly improved bowel function.
Publication: 11. May 2016 Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study.
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood. However, several lines of evidence suggest that the epigenetic instability in aging may be traced back to the alteration of the expression of DNA methyltransferases. Here, the association of the expression of DNA methyltransferases DNMT1 and DNMT3B with age has been analysed in the context of the MARK-AGE study, a large-scale cross-sectional study of the European general population.
Publication: 22. April 2016 Nutritional Biomarkers of Aging
The process of aging is determined by a complex interaction of endogenous factors such as genes combined with influencing exogenous factors such as nutrition and lifestyle. The progressive accumulation of damage caused by reactive species is often called oxidative stress and is associated with age-related diseases and aging. Defense mechanisms against oxidative stress involve the antioxidative network in which nutritional factors could intervene in a regulatory manner.
Publication: 15. March 2016 Using mid infrared technology as new method for the determination of the dwell time of salivary substitutes on three dimensional gingiva models
Many people suffer from dry mouth (xerostomia) due to radiotherapy treatment of head and neck cancer, diseases like Sjogren’s syndrome or as adverse effects to prescribed medications. Salivary substitute products like gels or sprays are often used for treatment. Efficacy of those oral care products are regularly assessed by validated or even not validated questionnaires. To determine the adhesion effect over time more objectively a new and sensitive method was established. The following study was designed to assess the dwell time of different oral care products in vitro.
Publication: 19. November 2015 In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation.
Mangifera indica fruit preparation (Careless™) activates the evolutionary conserved metabolic sensors sirtuin 1 and adenosine monophosphate-activated protein kinase, which have been identified as playing a key role in microcirculation and endothelial function. Here, an acute effect of a single dose of 100 mg or 300 mg Careless™ on microcirculation was investigated in a randomized, double-blind, crossover pilot study in ten healthy women to determine the effective dosage.
Publication: 09. July 2015 Quality control data of physiological and immunological biomarkers measured in serum and plasma.
In two work packages of the MARK-AGE project, 37 immunological and physiological biomarkers were measured in 3637 serum, plasma or blood samples in five batches during a period of 4 years. The quality of the serum and plasma samples was very good as judged by the low number of biomarker measurements (only 0.2%) that were rejected because of a high hemolysis, icteria or lipemia of the samples. Using quality control samples, day-to-day and batch variations were determined. The mean inter-assay variation of the five batches were all below 8%, with an average inter-assay coefficient of variation of all biomarkers of 4.0%.
Publication: 18. June 2015 Joint health: What degree of evidence is necessary to support health claims for food supplements, taking glucosamine as an example?
Arthropathies present a major challenge for the public health system, both in terms of epidemiology and health economics, particularly against the background of demographic changes in the Western world. Much attention must be paid to prevention, because of the limited options and high technical and financial expenditure with respect to treatment. Among other factors, nutrition plays an important role.
Publication: 01. May 2015 Wissenschaftliche Absicherung von Health Claims. Eine Bestandsaufnahme
Mit der VO (EG) Nr. 1924/2006 über nährwert- und gesundheitsbezogene Angaben über Lebensmittel (sog. „Health Claims Verordnung“ – HCV) wird Lebensmittelunternehmen die Möglichkeit eröffnet, Lebensmittel mit einer wirkbezogenen Aussage zu vermarkten. Acht Jahre nach dem Inkrafttreten der Verordnung sollen in der gebotenen Kürze regulatorische Entwicklungen in der Umsetzung der HCV nachvollzogen und Informationen zur Vorgehensweise bei der Zulassung von Health Claims gegeben werden. Darüber hinaus wird auf die Anforderungen an eine wissenschaftliche Absicherung von gesundheitsbezogenen Angaben und die dafür notwendigen Evidenzkriterien eingegangen. Von der EFSA wurden hohe Hürden für die wissenschaftliche Absicherung aufgestellt. Mit dem Artikel sollen Schwächen bei der bisherigen Vorgehensweise dargestellt werden, ein Überblick über die noch offenen Themen gegeben und Möglichkeiten zur Bewältigung der wissenschaftlichen Anforderungen aufgezeigt werden.
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